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Researchers Identify Cancer Cell Defect Driving Resistance to CAR T Cell Therapy

February 3, 2020

Some cancer cells refuse to die, even in the face of powerful cellular immunotherapies like CAR T cell…
New Nanoparticles are Less Toxic to T Cells Engineered for Cancer Immunotherapy

January 29, 2020

New cancer immunotherapies involve extracting a patient’s T cells and genetically engineering them so they will recognize and…
New Technique Predicts Which Melanoma Patients Are at Risk for Cancer Recurrence and Spread

January 21, 2020

For most patients, melanoma begins with a small, pigmented spot on their skin that they notice starts to…
Discovery of new T-cell raises prospect of ‘universal’ cancer therapy

January 21, 2020

T-cell therapies for cancer – where immune cells are removed, modified and returned to the patient’s blood to…
Team Sheds New Light on the Role of Regulatory T Cells in Pancreatic Cancer

January 13, 2020

In mouse models, the work uncovers a new potential target to improve immunotherapy approaches to the deadly disease.…
Molecular Missing Link’ May Explain Allergic Reactions to Personal Care Products

January 8, 2020

Chemical compounds found in skin creams and other personal care products can cause an allergic reaction in the…
Versatile bile acids

January 3, 2020

Could bile acids—the fat-dissolving juices churned out by the liver and gallbladder—also play a role in immunity and…
Researchers support new strategies for HIV control

December 19, 2019

The search for a cure to AIDS has partly focused on ways to eradicate infected cells. Now, new…
Study finds differences in energy use by immune cells in ME/CFS

December 13, 2019

New findings published in the Journal of Clinical Investigation suggest that specific immune T cells from people with…
Study sheds light on immune control of cancer

December 12, 2019

New findings could provide doctors with vital clues about how the immune system prevents cancer from recurring. The…
Transition to exhaustion: clues for cancer immunotherapy

December 5, 2019

Research on immune cells “exhausted” by chronic viral infection provides clues on how to refine cancer immunotherapy. The…
Precisely poking cells en masse to cure cancer

November 14, 2019

What if you could cure cancer by re-engineering patients’ cells to better target and destroy their own tumors?…
Early Results from First-In-U.S. Trial of CRISPR-Edited Immune Cells for Cancer Patients Suggest Safety of Approach

November 8, 2019

Abramson Cancer Center researchers to present initial safety data after treating three patients. Genetically editing a cancer patient’s…
To Monitor Cancer Therapy in the Body, Penn Researchers Tag CAR T Cells with Imaging Markers

November 8, 2019

With CAR T cell therapy, a patient’s own immune cells are genetically modified and inserted back into the…
Clues to improve cancer immunotherapy revealed

October 28, 2019

Cancer immunotherapy drugs trigger the body’s immune system to attack tumors and have revolutionized the treatment of certain…
“Back in Time”: Researchers Unravel the Early Makings of an Exhausted T Cell

October 21, 2019

The immune system struggles to defeat cancer or chronic infections because many of the T cells that leap…
Engineered T Cells May Be Harnessed to Kill Solid Tumor Cells

October 3, 2019

There is now a multitude of therapies to treat cancer, from chemotherapy and radiation to immunotherapy and small…
Immunologists identify T cell homing beacons for lungs

September 30, 2019

Scientists have identified a pair of molecules critical for T cells, part of the immune system, to travel…
Yale researchers identify rare inherited immune disease

September 26, 2019

When a 9-year-old girl with anemia, breathing problems, and recurrent infections sought help for her mysterious ailments, Yale…
CAR T-Cell Therapy May Be Harnessed to Treat Heart Disease

September 12, 2019

CAR T-cell therapy, a rapidly emerging form of immunotherapy using patients’ own cells to treat certain types of…
Stanford researchers probe the link between gut microbiota and cancer immunotherapy

August 29, 2019

Cancer immunotherapies have given patients with particularly intractable cancers new hope, but not everyone benefits. One such immunotherapy,…
Can a combination immune therapy reduce genital herpes outbreaks?

August 5, 2019

Yale investigators have shown that the combination of a vaccine and a medicated cream is a promising strategy…
Scientists discover immune cell subtype in mice that drives allergic reactions

August 5, 2019

Allergies can be life-threatening when they cause anaphylaxis, an extreme reaction with constriction of the airways and a…
UTA professor investigating the role of T cells in cardiovascular disease

July 29, 2019

A researcher at The University of Texas at Arlington’s College of Nursing and Health Innovation will use a $634,000 National…
Encephalitis identified as rare toxicity of immunotherapy treatment

July 26, 2019

After a cancer patient receiving an immunotherapy developed encephalitis and died 18 months into treatment, researchers at Vanderbilt-Ingram…
New vaccine strategy boosts T-cell therapy

July 15, 2019

A promising new way to treat some types of cancer is to program the patient’s own T cells…
Immune-boosting compound makes immunotherapy effective against pancreatic cancer

July 8, 2019

Pancreatic cancer is especially challenging to treat – only eight percent of patients are still alive five years…
Boosting the cancer-destroying ability of killer T-cells

July 2, 2019

The team of researchers discovered that increasing the amount of the molecule L-selectin on T-cells can vastly improve…
New knowledge on the development of asthma

June 27, 2019

Researchers at Karolinska Institutet have studied which genes are expressed in overactive immune cells in mice with asthma-like…
Structure of T cell epitopes a decisive factor in natural HIV control, study finds

May 13, 2019

In 2017, nearly 37 million people were living with HIV worldwide, according to the Joint United Nations Program…
International $6M Grant to Study HIV/TB Coinfection in Kids

May 3, 2019

About a third of us are walking around with the bacteria that causes tuberculosis (TB) in our bodies,…
Rare disease gives new insight into regulatory T cell function

April 24, 2019

An international study led from Karolinska Institutet provides new insights into the regulatory T cells’ role in protecting…
Turning patients’ own cells into cancer fighters

April 12, 2019

The next cancer therapy could be a patient’s own cells. Tactiva Therapeutics, a Buffalo-based immuno-oncology startup, is developing…
Scientists prod immune cells to attack pancreatic cancer

April 5, 2019

It’s possible to prod immune cells to attack and kill pancreatic cancer cells, according to a report from scientists…
Breakthrough Study of Cell Signaling Holds Promise for Immune Research and Beyond

April 2, 2019

A team of physical chemists led by Berkeley Lab has unraveled the inner workings of a process that…
Harnessing T-cell “stemness” could enhance cancer immunotherapy

April 1, 2019

A new study led by scientists in the Center for Cancer Research (CCR) at the National Cancer Institute…
UVA discovers secret to making immune cells better cancer killers

February 26, 2019

Scientists at the University of Virginia School of Medicine have discovered a defect in immune cells known as “killer T…
How the Body Fights Cancer and Intruders

February 1, 2019

The human body’s immune system is like a vast team of special agents. Certain cells called T cells…
Scientists design protein that prods cancer-fighting T-cells

January 11, 2019

New protein mimics interleukin-2 without toxic effects and works against cancer in an animal model. Scientists at UW…
The ‘Graying’ of T Cells

December 18, 2018

Scientists pinpoint metabolic pathway behind age-related immunity loss. The elderly suffer more serious complications from infections and benefit…
Suicide Handshakes Kill Precursor T Cells that Pose Autoimmune Dangers

November 14, 2018

Ball lands in cup; cup triggers spring; spring clamps lever tightly onto ball. That’s a rough description of newly…
Drivers of inflammation provide valuable targets for new gum disease therapies

October 25, 2018

T cells help fight off infection, but they can go overboard. A new study led by researchers at…
Discovering a single cell that leads to relapse

October 8, 2018

New research from the Abramson Cancer Center identified a rare cause for relapse in leukemia: a single leukemic cell engineered…
B Cells Among Factors Leading to Brain Lesions in Multiple Sclerosis

September 4, 2018

A team of researchers from UZH and USZ has shown that in multiple sclerosis, it is not only…
Components of the gene gun used in malaria vaccine and flu vaccine development.
Malaria vaccine work deploys parasite-fighting cells to liver

September 4, 2018

After an infected mosquito bite, malaria parasites travel from the bite site to the liver.  For that reason,…
Tackling T Cells

August 3, 2018

A pair of new studies led by investigators at Harvard Medical School and Boston Children’s Hospital looks to…
Gut’s ‘Taste Buds’ Help School the Immune System in the Thymus

July 19, 2018

UC San Francisco researchers were recently surprised to discover fully formed gut and skin cells in the thymus,…
T Cell Engineering Breakthrough Sidesteps Need for Viruses in CRISPR Gene-Editing

July 16, 2018

In an achievement that has significant implications for research, medicine, and industry, UC San Francisco scientists have genetically…
UCLA researchers develop synthetic T cells that mimic form, function of human version

June 26, 2018

Discovery could be a step toward developing treatments for cancer and autoimmune diseases. UCLA researchers have developed synthetic…
Fetal T cells are first responders to infection in adults

June 18, 2018

Cornell researchers have discovered there is a division of labor among immune cells that fight invading pathogens in…
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