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Moderate to Heavy Drinking During Pregnancy Alters Genes in Newborns, Mothers

August 21, 2019

Mothers who drink moderate to high levels of alcohol during pregnancy may be changing their babies’ DNA, according…
Study Links Epigenetic Age with Childhood Allergy, Asthma

May 3, 2019

Known as the atopic or allergic march, it’s a familiar progression to pediatricians and parents alike: atopic dermatitis…
Study identifies new genes associated with the leading cause of blindness

January 24, 2019

A new study, published in Clinical Epigenetics, identifies genes associated with Age-related Macular Degeneration (AMD) that could represent new…
Elevated hormone flags liver problems in mice with methylmalonic acidemia

December 10, 2018

Researchers have discovered that a hormone, fibroblast growth factor 21 (FGF21), is extremely elevated in mice with liver…
Harnessing Cancer’s Methylation Footprint for More Precise Diagnosis and Prognosis

June 29, 2017

In a new study researchers at University of California San Diego School of Medicine, with colleagues in Xijing Hospital…
Obesity reprograms muscle stem cells

February 22, 2017

Obesity is associated with reduced muscle mass and impaired metabolism. Epigenetic changes that affect the formation of new…
Patient-derived tumor xenograft models (PDXs) for ovarian cancer are suitable for future epigenetic methylome-based cancer research

November 9, 2016

Ovarian cancer is the most lethal gynecologic malignancy. After (epi)genomic analysis of patient tumors, aberrant DNA methylation patterns…
Gestational age estimated through DNA methylation

October 10, 2016

Researchers have developed a method for estimating developmental maturity of newborns. It is based on tracking DNA methylation,…
Scientists use CRISPR/CAS9 to flip DNA methylation states in vivo

September 22, 2016

Whitehead Institute scientists have deciphered how to use a modified CRISPR/Cas9 gene editing system to change genes’ methylation…
Inherited parental methylation shifts over time, may have functional effects in the brain and other tissues

September 21, 2016

Parental imprinting—a form of gene control passed down from parents to offspring—is far more dynamic than previously thought…
HIV Infection Prematurely Ages People by an Average of Five Years

April 23, 2016

Thanks to combination antiretroviral therapies, many people with HIV can expect to live decades after being infected. Yet…
‘Molecular movie’ opens door to new cancer treatments

February 9, 2016

An international team of scientists led by the University of Liverpool has produced a ‘structural movie’ revealing the…
When food alters gene function

February 2, 2016

As the study shows, a high-fat diet during pregnancy and lactation leads to epigenetic changes in the offspring.…
New biomarker to assess stem cells developed

January 31, 2016

A research team led by scientists from UCL have found a way to assess the viability of ‘manufactured’…
New findings challenge popular explanation for why a social insect becomes a worker or queen

January 23, 2016

The exquisite social hierarchy of insect colonies has long fascinated scientists. Take two eggs—both contain identical genetic material,…
Linking gene expression and DNA methylation in single cells

January 11, 2016

New method makes it possible to study the direct relationship between DNA methylation and gene expression in the…
Field widens for environments, microbes that produce toxic form of mercury

October 12, 2015

Thawing permafrost and contaminated sediment in marine coastal areas pose some of the greatest risks for the production…
New methodology tracks changes in DNA methylation in real time at single-cell resolution

September 26, 2015

Whitehead Institute researchers have developed a methodology to monitor changes in DNA methylation over time in individual cells.…
Premature aging of leukocyte DNA methylation is associated with type 2 diabetes prevalence

April 6, 2015

BACKGROUND: Type 2 diabetes mellitus (T2D) is highly prevalent in Middle-Eastern and North African Arab populations, but the…
Scientists discover how ‘jumping genes’ help black truffles adapt to their environment

August 25, 2014

Black truffles, also known as Périgord truffles, grow in symbiosis with the roots of oak and hazelnut trees.…
Identifying epigenetic markers in cancer cells could improve patient treatment

August 13, 2014

Scientists have known for decades that cancer can be caused by genetic mutations, but more recently they have…
DNA methylation switches in evolution: Evidence from whole methylome decoding in Helicobacter pylori

April 25, 2014

It is accepted in the mainstream of life sciences today that the basic unit of heredity is to…
High maternal folic acid could be as harmful as it is beneficial for fetal brain development

February 24, 2014

Dietary folic acid has long been associated with decreased risk of neurodevelopmental disorders, such as autism and birth…
Socioeconomic status, ethnicity and lifestyle choices are reflected by methylation patterns in a single gene

January 29, 2014

Is it possible that differences in a social status of human beings may impact the epigenetic changes in…
Epigenetic patterns observed in schizophrenia therapy may open up venues for personalized medicine

January 7, 2014

Olanzapine, a common antipsychotic drug used in schizophrenia treatment, is known to affect the epigenetic profile of the brain…
Preterm birth can leave a long term mark on DNA

December 16, 2013

Methylation is one of the main epigenetic markers, which can change during the course of life according to…
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