Google Play icon

Neutrons—Insight into human tissue

Posted 5 days ago

Researchers used neutron scattering at Oak Ridge National Laboratory’s Spallation Neutron Source and High Flux Isotope Reactor to better understand how certain cells in human tissue bond together.

As determined by small angle neutron scattering, this complex of proteins—alpha-catenin, shown in blue; beta-catenin, shown in purple; and E-cadherin, shown in yellow—is the central component of the adhesion junction, which transmits mechanical stress from cell to cell. Credit: Jill Hemman/Oak Ridge National Laboratory, U.S. Dept. of Energy

They learned that specialized cell-to-cell adhesion complexes, known as adherens junctions, use flexible proteins to attach themselves to neighboring cells and build larger biological structures. “Neutrons gave us a clear picture of how these adherens junctions work together to create more complicated cell-to-cell interactions, which is crucial for everything from embryo development to wound healing,” said ORNL’s Shuo Qian.

Published in PNAS, this research provides new insight into proteins involved in cancer and vascular disease, both of which have been linked to dysfunctional adherens junctions. Complementary measurements were made at SLAC National Accelerator Laboratory.—Gage Taylor

Source: ORNL

Featured news from related categories:

Technology Org App
Google Play icon
84,692 science & technology articles

Most Popular Articles

  1. Oumuamua 2.0? It Looks Like There is a New Interstellar Object Passing Through the Solar System (September 13, 2019)
  2. Real Artificial Gravity for SpaceX Starship (September 17, 2019)
  3. Top NASA Manager Says the 2024 Moon Landing by Astronauts might not Happen (September 19, 2019)
  4. How social media altered the good parenting ideal (September 4, 2019)
  5. What's the difference between offensive and defensive hand grenades? (September 26, 2019)

Follow us

Facebook   Twitter   Pinterest   Tumblr   RSS   Newsletter via Email