Google Play icon

Soldiers, athletes could have improved outcomes from traumatic brain injury through faster diagnosis using urine analysis

Share
Posted September 5, 2019

Scientists also report that even a mild hit or blast to the brain can benefit from early detection, treatment.

A traumatic brain injury is often easily suspected and can be confirmed and treated if necessary following an injury using a blood analysis, but scientists are reporting that even one mild blast to the brain can cause very subtle but permanent damage as well. Urine analysis taken within one week of a mild to traumatic brain injury also can provide faster diagnosis and treatment for such injuries.

A study led by Shi reports that checking the urine within seven days following such an injury, even a mild injury with no immediately obvious symptoms, could be less invasive, faster and help reduce the risk of long-term health issues including Parkinson’s disease.

“Even at one day post injury, a simple urine analysis can reveal elevations in the neurotoxin acrolein. The presence of this “biomarker” alerts us to the injury, creating an opportunity for intervention,” said Shi, who has appointments in Purdue’s College of Veterinary Medicine and Weldon School of Biomedical Engineering. “This early detection and subsequent treatment window could offer tremendous benefits for long-term patient neurological health.”

The research paper, titled “Acrolein-mediated Alpha-synuclein Pathology Involvement in the Early Post-injury Pathogenesis of Mild Blast-induced Parkinsonian Neurodegeneration, was published in July in the Journal of Molecular and Cellular Neuroscience.

“Most people have heard that traumatic brain injuries are linked to Parkinson’s, Alzheimer’s and other neurodegenerative diseases, dating back as far as to Muhammad Ali and even earlier,” Shi said. “The seriousness of this relationship is readily apparent; however, we want to, for the first time, implement a mechanism or protocol capable of connecting brain injuries to these diseases. We can accomplish this by testing for acrolein, which is well-researched and already recognized as a very important pathological factor in Parkinson’s disease. This study establishes a solid link between the two and opens the door for faster treatments utilizing acrolein urine tests during the days following a traumatic episode.”

In the research study, a urine analysis tested for an increased elevation of acrolein or oxidative stress within one week following a neurological injury.

“What’s important is that urine tests can be performed much easier than blood tests or other more invasive medical procedures currently available,” Shi said. “And it has been shown that individuals who experience brain injuries are three times more likely than their age-matched peers to develop neurological disease. If we can establish a protocol to routinely test urine following a traumatic brain injury, we can improve treatment options earlier and potentially offer better long-term outcomes.”

More than 500,000 people in the U.S. are currently living with Parkinson’s disease, and another 50,000 people are diagnosed with this neurodegenerative disorder every year, according to the National Institutes of Health.

The research was funded in part by the National Institutes of Health, the Indiana State Department of Health, and the Indiana CTSI Collaboration in Biomedical Translational Research Pilot Program.

Source: Purdue University, by Cynthia Sequin.

Featured news from related categories:

Technology Org App
Google Play icon
84,049 science & technology articles

Most Popular Articles

  1. Efficiency of solar panels could be improved without changing them at all (September 2, 2019)
  2. Diesel is saved? Volkswagen found a way to reduce NOx emissions by 80% (September 3, 2019)
  3. The famous old Titanic is disappearing into time - a new expedition observed the corrosion (September 2, 2019)
  4. The Time Is Now for Precision Patient Monitoring (July 3, 2019)
  5. Europe and US are Going to Try and Deflect an Asteroid (September 6, 2019)

Follow us

Facebook   Twitter   Pinterest   Tumblr   RSS   Newsletter via Email