Google Play icon

New single vaccination approach to killer diseases

Share
Posted May 21, 2019

Scientists from the University of Adelaide’s Research Centre for Infectious Diseases have developed a single vaccination approach to simultaneously combat influenza and pneumococcal infections, the world’s most deadly respiratory diseases.

The researchers say a single vaccination – combining vaccines from the new class of vaccines they are developing – will overcome the limitations of current influenza and pneumococcal vaccines used around the world.

Typical vaccination. Image credit: U.S. Air Force/Areca T. Wilson

Typical vaccination. Image credit: U.S. Air Force/Areca T. Wilson

Published in the prestigious journal Nature Microbiology, they have shown that the new Influenza A virus vaccine under development (based on inactivated whole influenza virus) induces enhanced cross-protective immunity to different influenza strains, when it is co-administrated with the new class of pneumococcal vaccine.

They showed the enhancement in immunity is associated with a direct physical interaction between the virus and the bacterium.

Led by Dr Mohammed Alsharifi and Professor James Paton, this latest study builds on previous research on the development of a new class of inactivated vaccines that target components of both the virus and the bacterium that do not vary from strain to strain.

Current influenza vaccines target surface molecules that are affected by mutations and so an annual update is required to match newly emerging viruses. Existing pneumococcal vaccines provide longer lasting protection, but cover only a minority of disease-causing strains. The researchers say there is a clear need for better vaccines capable of providing universal protection.

“Influenza infection predisposes patients to severe pneumococcal pneumonia, with very high mortality rates,” says Dr Alsharifi. “Despite this well-known synergism, current vaccination strategies target the individual pathogens.

“We’re investigating combining our novel influenza and pneumococcal vaccines into a single vaccination approach and have demonstrated a highly significant enhancement of immune responses against diverse subtypes of influenza.”

Previously published work from the team show a similar boost in efficacy of their pneumococcal vaccine when co-administered with the flu vaccine, so there is bi-directional enhancement of pathogen-specific immunity.

“Our findings challenge an age-old immunological dogma about mixing viral and bacterial vaccines in a single injection”, says Dr Alsharifi.

“Influenza virus and pneumococcus worked together to cause up to 100 million deaths during the great ‘Spanish flu’ pandemic of 1918-1919,” says Professor Paton.

“A century later, we have shown analogous, but this time highly protective, synergy with our novel vaccination strategy that targets both pathogens simultaneously.”

Source: University of Adelaide

Featured news from related categories:

Technology Org App
Google Play icon
83,898 science & technology articles

Most Popular Articles

  1. Efficiency of solar panels could be improved without changing them at all (September 2, 2019)
  2. Diesel is saved? Volkswagen found a way to reduce NOx emissions by 80% (September 3, 2019)
  3. The famous old Titanic is disappearing into time - a new expedition observed the corrosion (September 2, 2019)
  4. Moisturizers May Be Turning Your Skin Into "Swiss Cheese" (August 19, 2019)
  5. The Time Is Now for Precision Patient Monitoring (July 3, 2019)

Follow us

Facebook   Twitter   Pinterest   Tumblr   RSS   Newsletter via Email