Google Play icon

Researchers grow cells in ‘paper organs’

Share
Posted May 3, 2019

Long before scientists test new medicines in animals or people, they study the effects of the substances on cells growing in Petri dishes. However, a 2D layer of cells is a poor substitute for the much more complex 3D structure of tissues in organs. Now, researchers reporting in the ACS journal Nano Letters have used a 3D printer to make paper organs, complete with artificial blood vessels, that they can populate with cells.

Petri dish and other tools for biochemical research. Image credit: Pxhere, CC0 Public Domain

Petri dish and other tools for biochemical research. Image credit: Pxhere, CC0 Public Domain

In the body, tissues with similar functions are grouped together in organs, such as the brain, heart or stomach. Organs also contain supporting cells, including nerves, blood vessels and connective tissues. An organ’s 3D architecture provides biological, structural and mechanical support to cells that influences how they grow and respond to external stimuli, such as medicines.

Yu Shrike Zhang and colleagues wanted to see whether they could combine 3D printing and bacterial cellulose to make supports for artificial organs that they could then fill with cells. Cellulose, a polysaccharide made by plants, algae and some bacteria, is a low-cost material used to make paper.

To create a breast tumor model, the researchers 3D printed petroleum jelly-paraffin ink into a bacterial cellulose hydrogel. Then, they air-dried the hydrogel so that it became porous and paper-like. When they heated the ink, it liquefied and was easy to remove, leaving behind hollow microchannels. The team wet the paper “organ” and added endothelial cells — the cell type that lines blood vessels — to the microchannels, and added breast cancer cells to the rest of the structure. Dried paper organs can be stored for long periods of time and then rehydrated to produce inexpensive tissue models, which could be useful for drug screening and personalized medicine, the researchers say.

Source: acs.org

Featured news from related categories:

Technology Org App
Google Play icon
85,970 science & technology articles

Most Popular Articles

  1. Universe is a Sphere and Not Flat After All According to a New Research (November 7, 2019)
  2. NASA Scientists Confirm Water Vapor on Europa (November 19, 2019)
  3. This Artificial Leaf Turns Atmospheric Carbon Dioxide Into Fuel (November 8, 2019)
  4. How Do We Colonize Ceres? (November 21, 2019)
  5. A stretchable stopwatch lights up human skin (November 4, 2019)

Follow us

Facebook   Twitter   Pinterest   Tumblr   RSS   Newsletter via Email