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Mom’s gestational diabetes hikes kids’ pre-diabetes, obesity risk

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Posted January 22, 2019

Up to 20 percent of women develop gestational diabetes – high blood sugar – during pregnancy, but the long-term effects on their children haven’t been known.

Now, the first study to analyze the long-term effects found the 10-to-14-year-old children of women who had untreated gestational diabetes are more likely to have pre-diabetes and obesity than children whose mothers did not have higher blood sugar, Northwestern Medicine investigators report.

Image credit: Walter Siegmund via Wikimedia, GFDL

Image credit: Walter Siegmund via Wikimedia, GFDL

It’s already known obesity in the mother or a genetic predisposition for diabetes contributes to a risk for both obesity and diabetes in the next generation.

“Our study shows that independent of a mother’s weight or genetic predisposition to diabetes, a mother’s blood sugar level during pregnancy independently adds to the risk of both obesity and glucose intolerance in her child,” said lead investigator Dr. Boyd Metzger, professor emeritus of medicine at Northwestern University Feinberg School of Medicine.

The paper was published in the journal Diabetes Care.

Gestational diabetes is a condition in which a woman without diabetes develops high blood sugar levels during pregnancy. It increases the risk of pre-eclampsia, depression, Caesarean section and stillbirth.

“The fact that these conditions in the child at 11 years of age are related to the mom’s glucose level in her pregnancy is an additional reason gestational diabetes should be identified and treated,” Metzger said. “We do know that treatment will reduce immediate newborn complications but don’t know yet if it will reduce prediabetes in the older child.

“The mother’s glucose metabolism during her pregnancy (her ability to process sugar) affects her child’s glucose metabolism. We don’t understand why yet,” Metzger said.

The large international Hyperglycemia and Adverse Pregnancy Outcome Follow-Up Study (HAPO FUS) included 4,160 children ages 10 to 14 years who completed all or part of an oral glucose tolerance test and whose mothers had gestational diabetes at 28 weeks of pregnancy.

Source: Northwestern University

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