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3D bioprinting technique could create artificial blood vessels, organ tissue

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Posted October 22, 2018

CU Boulder engineers have developed a 3D printing technique that allows for localized control of an object’s firmness, opening up new biomedical avenues that could one day include artificial arteries and organ tissue.

The study, which was recently published in the journal Nature Communications, outlines a layer-by-layer printing method that features fine-grain, programmable control over rigidity, allowing researchers to mimic the complex geometry of blood vessels that are highly structured and yet must remain pliable.

Orthogonal programming of matrix stiffness and geometry via oxygen inhibition-assisted stereolithography. Image credit: <a href="https://www.nature.com/articles/s41467-018-06685-1#article-info">Hang Yin et.al.</a>, Creative Commons CC-BY-4.0

Orthogonal programming of matrix stiffness and geometry via oxygen inhibition-assisted stereolithography. Image credit: Hang Yin et.al., Creative Commons CC-BY-4.0

The findings could one day lead to better, more personalized treatments for those suffering from hypertension and other vascular diseases.

Xiaobo Yin, an associate professor in CU Boulder’s Department of Mechanical Engineering and the senior author of the study, said:

“The idea was to add independent mechanical properties to 3D structures that can mimic the body’s natural tissue. […] This technology allows us to create microstructures that can be customized for disease models.”

Hardened blood vessels are associated with cardiovascular disease, but engineering a solution for viable artery and tissue replacement has historically proven challenging. To overcome these hurdles, the researchers found a unique way to take advantage of oxygen’s role in setting the final form of a 3D-printed structure.

Yonghui Ding, a postdoctoral researcher in Mechanical Engineering and the lead author of the study, said:

“Oxygen is usually a bad thing in that it causes incomplete curing. […] Here, we utilize a layer that allows a fixed rate of oxygen permeation.”

By keeping tight control over oxygen migration and its subsequent light exposure, Ding said, the researchers have the freedom to control which areas of an object are solidified to be harder or softer—all while keeping the overall geometry the same.

“This is a profound development and an encouraging first step toward our goal of creating structures that function like a healthy cell should function,” Ding said.

As a demonstration, the researchers printed three versions of a simple structure: a top beam supported by two rods. The structures were identical in shape, size and materials, but had been printed with three variations in rod rigidity: soft/soft, hard/soft and hard/hard. The harder rods supported the top beam while the softer rods allowed it to fully or partially collapse.

The researchers repeated the feat with a small Chinese warrior figure, printing it so that the outer layers remained hard while the interior remained soft, leaving the warrior with a tough exterior and a tender heart, so to speak.

The tabletop-sized printer is currently capable of working with biomaterials down to a size of 10 microns, or about one-tenth the width of a human hair. The researchers are optimistic that future studies will help improve the capabilities even further.

Xiaobo Yin added:

“The challenge is to create an even finer scale for the chemical reactions. […] But we see tremendous opportunity ahead for this technology and the potential for artificial tissue fabrication.”

Additional co-authors of the new study include Hang Yin, Yao Zhai and Associate Professor Wei Tan of Mechanical Engineering. The National Science Foundation and the National Institutes of Health provided funding for the research.

Source: University of Colorado Boulder, by Trent Knoss.

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