Google Play icon

Chronic Inflammation Can Trigger Cancers Via Newly Discovered Mechanism

Share
Posted August 31, 2018

It is well known that extended exposure to the sun’s UV rays can cause DNA mutations that lead to skin cancer. Now new research reveals that inflammation from chronic skin injury can trigger cancer-causing mutations as well by a totally distinct mechanism.

The researchers – led by scientists at UC San Francisco and Thomas Jefferson University in Philadelphia, in collaboration with Santa Cruz-based Nantomics LLC – say that better understanding this previously invisible driver of tumor formation could lead to a new class of therapies for a variety of cancers.

A microscopic view of an invasive squamous cell cancer that stemmed from a rare skin disorder called recessive dystrophic epidermolysis bullosa (RDEB), or Butterfly Syndrome. Image credit: Andrew South

“We’re describing for the first time a mechanism that instigates tissue damage-driven cancers,” said study senior author Andrew South, PhD, an associate professor in the Department of Dermatology and Cutaneous Biology at Jefferson.

Previous studies of patients with head and neck cancers have suggested a link between tissue inflammation and cancer, but the specific mechanism behind this connection has remained elusive.

In their new study, published in Science Translational Medicine, South and UCSF Health dermatologist and geneticist Raymond Cho, MD, PhD, the study’s first author, studied the cells of children with a rare skin disorder called recessive dystrophic epidermolysis bullosa (RDEB). Patients with RDEB, sometimes called “butterfly children” because their skin’s extreme fragility calls to mind a butterfly’s wings, lack the connective protein collagen, which makes their skin prone to blistering and scarring at the slightest touch. In addition to severe pain and potential disfigurement, patients also frequently develop aggressive squamous cell cancers early in life in frequently injured areas.

h developed in the Cho lab at UCSF, the researchers ruled out problems with DNA repair, which is a common driver of increased levels of mutation in many cancers. Patterns of mutation density throughout the genome of RDEB tissue samples indicated that normal DNA repair mechanisms were functioning properly, confirming that the cancer-causing mutations seen in RDEB patients were a result of inflammation and dysfunctional APOBEC alone.

The notion that inflammation and cancer are somehow linked has been gaining traction both in the medical world and in the general public, according to Cho, who hopes the new findings will help make further investigations of this relationship – in skin cancers, head and neck cancers and other conditions – more concrete.

“In many ways, cancers are akin to wounds that never heal,” Cho said. “Here we’re showing a new mechanism for how inflammation from chronic tissue damage can actually lead to cancer. This could present the medical community with new opportunities to develop preventive measures against inflammation-driven cancers, as we have done successfully with cancers caused by UV exposure.”

Source: UCSF

Featured news from related categories:

Technology Org App
Google Play icon
83,394 science & technology articles

Most Popular Articles

  1. Bright Fireball Explodes Over Ontario, Meteorite Fragments Might Have Reached the Ground (August 5, 2019)
  2. Why older people smell the way they do? Japanese have even a special word for it (August 4, 2019)
  3. Terraforming the Surface of Mars with Silica Aerogel? (July 23, 2019)
  4. Moisturizers May Be Turning Your Skin Into ‘Swiss Cheese’ (4 days old)
  5. Swarm Autonomy Tested in Second Major DARPA OFFSET Field Experiment (August 8, 2019)

Follow us

Facebook   Twitter   Pinterest   Tumblr   RSS   Newsletter via Email