Google Play icon

Scientists compare distant relatives for clues to cell “family tree”

Share
Posted August 29, 2018

Among animal species, cell types vary greatly in their number and kind, playing an important role in the structural and functional diversity of all organisms. But the molecular mechanisms that determine the evolution of novel cell types are poorly understood.

Cells with similar functions, or cell types, in different animal species are related both by an evolutionary line of descent similar to the relatedness of species themselves and by a developmental line of descent in the embryo.

Image credit: Yale University

Critical to comprehending fundamental aspects of human biology, Yale scientists have moved closer to resolving the riddle of how new cell types arise by studying tissue cells from the uterus of humans and opossums, two distantly related mammals.

Published in the journal PLOS Biology, researchers at Yale’s Systems Biology Institute describe how a novel cell type – the decidual stromal cell – evolved by rewiring an ancestral cellular stress response, an important mechanism in the evolution of this cell type.

The evolution of mammalian pregnancy offers an opportunity to investigate cell type origination. Selection pressures during the evolution of mammalian pregnancy led to the evolution of many functional specializations of the uterus that accommodate the implantation of the embryo and development of the placenta, including proper control of an ancestral implantation-induced inflammatory response.

By treating precursor decidual cells with “pregnancy signals”, the researchers were able to compare differences in the way opossum and human genes were expressed. Surprisingly, the scientists found that opossum cells induced a stress response using a similar set of regulatory genes as their human counterparts. In the human cells, these same signals induce differentiation into decidual cells.

Image credit: Yale University

The results suggest that a network of genes responsible for responding to pregnancy-related stress was hijacked and repurposed to function in a different way.

“We are in an age of medicine and therapeutics where we need to know how cells function, and for that it helps to know how cells evolved,” said first author Eric Erkenbrack, a post-doctoral associate in the Gunter Wagner laboratory.

Recent advances in both developmental genetics and complex systems theory are fundamentally changing how scholars think about the evolution of organisms. The laboratory of senior author Gunter Wagner investigates how complex characters evolve by random mutation and selection, and through “homology thinking,” an approach developed by Wagner that questions how traits originate rather than how they get modified once established.

“This is an exciting discovery which shows that environmentally induced gene expression can turn into a genetically fixed novel character in a species,” said Wagner, the Alison Richard Professor of Ecology and Evolutionary Biology.

Source: Yale University

Featured news from related categories:

Technology Org App
Google Play icon
83,279 science & technology articles

Most Popular Articles

  1. Bright Fireball Explodes Over Ontario, Meteorite Fragments Might Have Reached the Ground (August 5, 2019)
  2. Why older people smell the way they do? Japanese have even a special word for it (August 4, 2019)
  3. Terraforming the Surface of Mars with Silica Aerogel? (July 23, 2019)
  4. Swarm Autonomy Tested in Second Major DARPA OFFSET Field Experiment (August 8, 2019)
  5. Dark Matter may Predate even the Big Bang Itself, New Study Suggest (August 8, 2019)

Follow us

Facebook   Twitter   Pinterest   Tumblr   RSS   Newsletter via Email