Google Play icon

Understanding the immunobiology of wild mammals

Posted April 20, 2018

The state of the immune system of wild animals is, remarkably, almost unknown.

However, knowing this and knowing what affects the immune state of wild animals is important in understanding how infection and disease affects wild animals.

Knowing the immune state of wild animals is also important in understanding the biology of the germs or pathogens that infect them. This is also directly relevant when trying to understand how germs are passed from one species to another, including to humans.

Mouse. Image credit: btfrewinphotography via Pixabay, CC0 Public Domain

Professor Mark Viney from the University of Bristol’s School of Biological Sciences, and the lead author of the new research, published in the journal, PLoS Biology, said:

“Our lack of knowledge about wild animals’ immune state is in stark contrast to our exquisitely detailed understanding of the immunobiology of laboratory animals.

“Many factors, individually, have been shown to constrain or to promote immune responses. These factors include age, sex, infection status, and body condition.

“However, the extent to which these different factors actually affect how animals recognise and defend themselves against bacteria, viruses and other infections is relatively unknown.”

In the new study, a joint project with the London School of Hygiene and Tropical Medicine and the University of Edinburgh’s Roslin Institute, the team investigated the immune ecology of wild house mice – the same species as the laboratory mouse – as an example of a wild mammal, characterising their adaptive humoral, adaptive cellular and innate immune state.

They first found that neighbouring populations of wild mice – on different farms, for example – were often in a very different immune state, the first time that this has been seen.

Secondly, they identified the main factors that underlie the immunological differences among individual mice, showing that mice with good body condition had enhanced immune responses. In general, older mice had a poorer immune state but older animals also had better body condition, allowing them to partially resist the effects of their older age on their immune systems.

Professor Viney added: “By applying a multifactorial analysis to an immune system-wide analysis, our results bring a new and unified understanding of the immunobiology of a wild mammal.”

Professor Eleanor Riley, senior co-author of the paper from the Roslin Institute, University of Edinburgh commented: “Understanding which of many key drivers of the immune response are actually most important in allowing an individual animal to withstand infection is crucial to understanding how infections move among and between populations, how epidemics spread or can be contained, and how infections can jump species barriers to cause disease in new host populations.”

Source: University of Bristol

Featured news from related categories:

Technology Org App
Google Play icon
83,316 science & technology articles

Most Popular Articles

  1. Bright Fireball Explodes Over Ontario, Meteorite Fragments Might Have Reached the Ground (August 5, 2019)
  2. Why older people smell the way they do? Japanese have even a special word for it (August 4, 2019)
  3. Terraforming the Surface of Mars with Silica Aerogel? (July 23, 2019)
  4. Swarm Autonomy Tested in Second Major DARPA OFFSET Field Experiment (August 8, 2019)
  5. Dark Matter may Predate even the Big Bang Itself, New Study Suggest (August 8, 2019)

Follow us

Facebook   Twitter   Pinterest   Tumblr   RSS   Newsletter via Email