Google Play icon

Stem cells also rust

Share
Posted October 27, 2016
Research shows how stem cells are also affected negatively affected by oxidation and rust. Photo: L. Harboe

Research shows how stem cells are negatively affected by oxidation and rust. Photo: L. Harboe

Oxygen in the air is well known to cause damaging rust on cars through a process known as oxidation. Similarly, a research group at Lund University in Sweden, has now identified that certain cells during embryonic development also are negatively affected by oxidation. This oxidation is capable of leading to a block in cellular function.

The researchers use a laboratory based culture system to generate new blood from pluripotent stem cells. They hope in the future to be able to use the system to generate new blood cells, including blood stem cells, for patients in need of bone marrow transplants. However, laboratories worldwide attempting to generate laboratory derived blood cells, find these cells do not perform as well as blood cells from donor sources. The cells appear normal but do not grow and expand as well.

When investigating why the derived blood cells did not function as well as donor blood cells, the Lund University researchers found high levels of reactive oxygen species (a class of molecules that cause oxidation) in the newly derived blood cells. The levels were high enough to damage the cells and cause them not to grow in culture. The researchers have also developed a cocktail of factors that could reduce oxidative damage in the cells, and when used resulted in over twenty times more newly generated blood stem cells that could grow.

“By identifying the negative role of oxidation in new blood cells derived from pluripotent stem cells, we have identified what is perhaps the most significant hurdle in developing laboratory derived blood stem cells for transplantation based therapies.”, says Niels-Bjarne Woods, who is leading the study.

Source: Lund University

Featured news from related categories:

Technology Org App
Google Play icon
85,355 science & technology articles

Most Popular Articles

  1. New treatment may reverse celiac disease (October 22, 2019)
  2. "Helical Engine" Proposed by NASA Engineer could Reach 99% the Speed of Light. But could it, really? (October 17, 2019)
  3. New Class of Painkillers Offers all the Benefits of Opioids, Minus the Side Effects and Addictiveness (October 16, 2019)
  4. The World's Energy Storage Powerhouse (November 1, 2019)
  5. Plastic waste may be headed for the microwave (October 18, 2019)

Follow us

Facebook   Twitter   Pinterest   Tumblr   RSS   Newsletter via Email