Google Play icon

Fibroblast growth factor signalling controls fin regeneration in zebrafish

Share
Posted August 4, 2016

The early Fgf signal mediated by Fgf20 from the wound epidermis induces blastema formation by acting on the underlying mesenchymal cells. At a later stage, Fgf3 up-regulated in the blastema functions as a mitogen and promotes cell proliferation.

Unlike mammals, certain species of amphibians and fish have the remarkable ability to regenerate tissue. Advances in molecular biological analyses have allowed researchers to identify specific molecules and signalling mechanisms involved in tissue regeneration. Fgf signalling is one such key mechanism.

Associate Professor Atsushi Kawakami and colleagues at Tokyo Institute of Technology and the Graduate University for Advanced Studies (SOKENDAI) identified fgf20a and fgf3/10a as major fgf ligands in wound epidermis and blastemas, respectively. To observe the role of Fgf signalling in regeneration, they transplanted Fgf signalling-deficient mesenchymal cells into wild-type zebrafish. Their findings suggest that Fgf signals act directly on fin ray mesenchyme to form a blastema at the early pre-blastema stage and activate regenerative cell proliferation at the post-blastema stage. This further implies that the early epidermal Fgf20a and later blastemal Fgf3/10a could be responsible for the respective processes. Through gain-of-function analyses, they demonstrated that Fgf20a induces distal blastemal formation and Fgf3 promotes blastema cell proliferation. Their study highlights the distinct functions of Fgfs in wound epidermis and blastemas, acting cooperatively to regulate fin regeneration (Figure).

Fgf20 and Fgf3 are present in all vertebrate species, and further study may lead to clues on inducing tissue regeneration in mammals, including humans. Many challenges remain, however, such as determining what makes Fgf20 activate in wounded epidermis, and how cell proliferation leads to complete recovery of tissue shape and function.

Source: Tokyo Institute of Technology

Featured news from related categories:

Technology Org App
Google Play icon
85,381 science & technology articles

Most Popular Articles

  1. New treatment may reverse celiac disease (October 22, 2019)
  2. "Helical Engine" Proposed by NASA Engineer could Reach 99% the Speed of Light. But could it, really? (October 17, 2019)
  3. New Class of Painkillers Offers all the Benefits of Opioids, Minus the Side Effects and Addictiveness (October 16, 2019)
  4. The World's Energy Storage Powerhouse (November 1, 2019)
  5. Plastic waste may be headed for the microwave (October 18, 2019)

Follow us

Facebook   Twitter   Pinterest   Tumblr   RSS   Newsletter via Email