Google Play icon

Discovery of the characteristics of subcortical regions in schizophrenia

Share
Posted March 19, 2016

These are subcortical structures.

The existence of an asymmetry for globus pallidus volume

A research group led by Ryota Hashimoto, an associate professor at Osaka University, Naohiro Okada, a graduate student at the University of Tokyo, and Kiyoto Kasai, a professor at the University of Tokyo, replicated prior findings that the volume of globus pallidus (one of the basal ganglia in the brain) in schizophrenia was larger than that in healthy subjects. Also, the group found that patients with schizophrenia demonstrated a specific leftward volumetric asymmetry for the globus pallidus.

They compared and analyzed magnetic resonance imaging (MRI) brain images of 1,680 healthy individuals and 884 patients with schizophrenia from 11 research institutes participating in Cognitive Genetics Collaborative Research Organization (COCORO), and examined the differences between schizophrenia and healthy controls in the subcortical regional volumes and their asymmetries.

Compared to controls, patients with schizophrenia demonstrated smaller bilateral hippocampus, amygdala, thalamus and accumbens volumes as well as intracranial volume, but larger bilateral caudate, putamen, pallidum and lateral ventricle volumes. Also, patients with schizophrenia demonstrated a specific leftward asymmetry for globus pallidus volume.

These results suggest the possibility of aberrant laterality in neural pathways and connectivity patterns related to the globus pallidus in schizophrenia. Further, through the elucidation of the underlying pathological mechanisms, it will be a step toward the development of therapeutic strategies for schizophrenia.

Source: EurekAlert

Featured news from related categories:

Technology Org App
Google Play icon
85,465 science & technology articles

Most Popular Articles

  1. New treatment may reverse celiac disease (October 22, 2019)
  2. The World's Energy Storage Powerhouse (November 1, 2019)
  3. "Helical Engine" Proposed by NASA Engineer could Reach 99% the Speed of Light. But could it, really? (October 17, 2019)
  4. Plastic waste may be headed for the microwave (October 18, 2019)
  5. Universe is a Sphere and Not Flat After All According to a New Research (November 7, 2019)

Follow us

Facebook   Twitter   Pinterest   Tumblr   RSS   Newsletter via Email