Google Play icon

Atherosclerosis: a chronic inflammatory disease mediated by mast cells

Share
Posted February 1, 2016
This news or article is intended for readers with certain scientific or professional knowledge in the field.

Inflammation is a process that plays an important role in the initiation and progression of atherosclerosis and immune disease, involving multiple cell types, including macrophages, T-lymphocytes, endothelial cells, smooth muscle cells and mast cells.

The fundamental damage of atherosclerosis is the atheromatous or fibro-fatty plaque which is a lesion that causes several diseases. In atherosclerosis the innate immune response, which involves macrophages, is initiated by the arterial endothelial cells which respond to modified lipoproteins and lead to Th1 cell subset activation and generation of inflammatory cytokines and chemoattractant chemokines.

Other immune cells, such as CD4+ T inflammatory cells, which play a critical role in the development and progression of atherosclerosis, and regulatory T cells [Treg], which have a protective effect on the development ofatherosclerosis are involved. Considerable evidence indicates that mast cells and their products play a key role in inflammation and atherosclerosis. Activated mast cells can have detrimental effects, provoking matrix degradation, apoptosis, and enhancement as well as recruitment of inflammatory cells, which actively contributes to atherosclerosis and plaque formation. Here we discuss the relationship between atherosclerosis, inflammation and mast cells.

Source: Cent Eur J Immunol. 2015;40(3):380-6. doi: 10.5114/ceji.2015.54603. Epub 2015 Oct 15.

Featured news from related categories:

Technology Org App
Google Play icon
87,043 science & technology articles

Most Popular Articles

  1. You Might Not Need a Hybrid Car If This Invention Works (January 11, 2020)
  2. Toyota Raize a new cool compact SUV that we will not see in this part of the world (November 24, 2019)
  3. An 18 carat gold nugget made of plastic (January 13, 2020)
  4. Human body temperature has decreased in United States, study finds (January 10, 2020)
  5. Donkeys actually prefer living in hot climate zones (January 6, 2020)

Follow us

Facebook   Twitter   Pinterest   Tumblr   RSS   Newsletter via Email