Google Play icon

Unique Features of Cortical Bone Stem Cells Associated with Repair of the Injured Heart

Posted October 29, 2015
This news or article is intended for readers with certain scientific or professional knowledge in the field.


Adoptive transfer of multiple stem cell types has only had modest effects on the structure and function of failing human hearts. Despite increasing use of stem cell therapies, consensus on the optimal stem cell type is not adequately defined. The modest cardiac repair and functional improvement in patients with cardiac disease warrants identification of a novel stem cell population that possesses properties that induce a more substantial improvement in heart failure patients.


To characterize and compare surface marker expression, proliferation, survival, migration and differentiation capacity of Cortical Bone Stem Cells (CBSCs) relative to mesenchymal stem cells (MSCs) and cardiac derived stem cells (CDCs), that have already been tested in early stage clinical trials.


CBSCs, MSCs and CDCs were isolated from Gottingen miniswine or transgenic C57/BL6 mice expressing enhanced green fluorescent protein and were expanded in-vitro. CBSCs possess a unique surface marker profile including high expression of CD61 and Integrin Beta-4 versus CDCs and MSCs. Additionally CBSCs were morphologically distinct and showed enhanced proliferation capacity versus CDCs and MSCs. CBSCs had significantly better survival after exposure to an apoptotic stimuli as compared to MSCs. ATP and histamine induced a transient increase of intracellular Ca2+ concentration in CBSCs versus CDCs and MSCs which either respond to ATP or histamine only further documenting the differences between the three cell types.


CBSCs are unique from CDCs and MSCs and possess enhanced proliferative, survival and lineage commitment capacity that could account for the enhanced protective effects after cardiac injury.

Source: PubMed

Featured news from related categories:

Technology Org App
Google Play icon
85,381 science & technology articles

Most Popular Articles

  1. New treatment may reverse celiac disease (October 22, 2019)
  2. "Helical Engine" Proposed by NASA Engineer could Reach 99% the Speed of Light. But could it, really? (October 17, 2019)
  3. New Class of Painkillers Offers all the Benefits of Opioids, Minus the Side Effects and Addictiveness (October 16, 2019)
  4. The World's Energy Storage Powerhouse (November 1, 2019)
  5. Plastic waste may be headed for the microwave (October 18, 2019)

Follow us

Facebook   Twitter   Pinterest   Tumblr   RSS   Newsletter via Email