Google Play icon

Effects of maternal age on the expression of mesenchymal stem cell markers in the components of human umbilical cord

Posted September 29, 2015
This news or article is intended for readers with certain scientific or professional knowledge in the field.


Although the human umbilical cord (UC) has been previously considered a medical waste, its use as a main source of fetal stemcells for regenerative medicine applications has increased over the past few years. The aim of the study was to assess the impact of the maternal age on the expression of mesenchymal stem cells (MSC) markers CD105 and CD29 in the different areas of human UC.


In this comparative cross sectional study, one hundred term UCs from five maternal age groups (20-45 years) were collected after delivery from healthy mothers and were processed to assess both immuno- and gene expression of CD105 and CD29 surface antigen markers using immunohistochemical and RT-PCR techniques.


The immunoexpression of CD105 and CD29 in the amniotic membrane (AM) and Wharton ̛s jelly (WJ), the umbilical artery (UA) and the umbilical vein (UV) showed significant negative correlation with the maternal age (p < 0.001). Reduced amount of cells as well as the studied MSC markers and their gene expression levels were documented in older age mothers. CD105-positive MSCs were more abundant in the UA, whereas CD29-positive MSCs were more abundant in the AM and WJ.


The decreased expression of CD105 and CD29 MSCs markers with age suggests that selective isolation of MSCs from Wharton ̛s jelly, umbilical artery or umbilical vein of younger mothers should be recommended.

Source: PubMed

Featured news from related categories:

Technology Org App
Google Play icon
86,965 science & technology articles

Most Popular Articles

  1. You Might Not Need a Hybrid Car If This Invention Works (January 11, 2020)
  2. Toyota Raize a new cool compact SUV that we will not see in this part of the world (November 24, 2019)
  3. An 18 carat gold nugget made of plastic (January 13, 2020)
  4. Human body temperature has decreased in United States, study finds (January 10, 2020)
  5. Donkeys actually prefer living in hot climate zones (January 6, 2020)

Follow us

Facebook   Twitter   Pinterest   Tumblr   RSS   Newsletter via Email