Google Play icon

Biochemists Devise New Technique for Blueprinting Cell Membrane Proteins

Share
Posted June 5, 2015

Biochemists from Trinity College Dublin have devised a new technique that will make the difficult but critical job of blueprinting certain proteins considerably faster, easier and cheaper.1433435967_IMISX Data Screen

The breakthrough will make a big splash in the field of drug discovery and development, where precise protein structure blueprints can help researchers understand how individual proteins work. Critically, these blueprints can show weaknesses that allow drug developers to draw up specific battle plans in the fight against diseases and infections.

Professor of Membrane Structural and Functional Biology at Trinity, Martin Caffrey, is the senior author of the research, which has just been published in the international peer-reviewed journal Acta Crystallographica D.

Over 50% of drugs on the market target cell membrane proteins, which are vital for the everyday functioning of complex cellular processes. They act as transporters to ensure that specific molecules enter and leave our cells, as signal interpreters important in decoding messages and initiating responses, and as agents that speed up appropriate responses.

The major challenge facing researchers is the production of large membrane protein crystals, which are used to determine the precise 3-D structural blueprints. That challenge has now been lessened thanks to the Trinity biochemists’ advent – the in meso in situ serial crystallography (IMISX) method.

Beforehand, researchers needed to harvest protein crystals and cool them at inhospitable temperatures in a complex set of events that was damaging, inefficient and prone to error. The IMISX method allows researchers to determine structural blueprints as and where the crystals grow.

Source: Trinity College Dublin

Featured news from related categories:

Technology Org App
Google Play icon
87,551 science & technology articles

Most Popular Articles

  1. An 18 carat gold nugget made of plastic (January 13, 2020)
  2. Anti Solar Cells: A Photovoltaic Cell That Works at Night (February 3, 2020)
  3. Toyota Raize is a new cool compact SUV that we will not see in this part of the world (November 24, 2019)
  4. Nuclear waste could be recycled for diamond battery power (January 21, 2020)
  5. Physicist Proposes a Testable Theory Stating that Information has Mass and could Account for Universe s Dark Matter (January 24, 2020)

Follow us

Facebook   Twitter   Pinterest   Tumblr   RSS   Newsletter via Email