QUT biofabrication team has made a major breakthrough by 3D printing mechanically reinforced, tissue engineered constructs for the regeneration of body parts.
In an article published in Nature Communications, the biomedical engineers outlined how they had reinforced soft hydrogels via a 3D printed scaffold.
Professor Dietmar W. Hutmacher, from QUT’s Institute of Health and Biomedical Innovation, said nature often used fibre reinforcement to turn weak structures into outstanding mechanically robust ones.
“Such is the case with articular cartilage tissue, which is formed by stiff and strong collagen fibres intertwined within a very weak gel matrix of proteoglycans,” Professor Hutmacher said.
“By bringing this natural design perspective of fibre reinforcement into the field of tissue engineering (TE), we can learn a lot about how to choose an effective combination of matrix and reinforcement structure in order to achieve composite materials with enhanced mechanical properties for engineering body parts.”
Professor Hutmacher said hydrogels were favoured because they had excellent biological properties, however, the hydrogels currently available for tissue regeneration of the musculoskeletal system couldn’t meet the mechanical and biological requirements for successful outcomes.
“Our international biofabrication research team has found a way to reinforce these soft hydrogels via a 3D printed scaffold structure so that their stiffness and elasticity are close to that of cartilage tissues.”
Professor Hutmacher said the team had introduced organised, high-porosity microfiber networks that are printed using a new technique called “melt electrospinning writing”.
“We found that the stiffness of the gel/scaffold composites increased synergistically up to 54 times, compared with hydrogels or microfiber scaffolds alone,” he said.
“Computational modelling has shown that we can use these 3D-printed microfibres in different hydrogels and a large range of tissue engineering applications.”