Google Play icon

Intellectual property on pediatric cancer is dedicated to the public

Share
Posted April 3, 2015

Intellectual property resulting from the discovery of specific DNA mutations linked to a rare and often deadly type of adolescent liver cancer, fibrolamellar hepatocellular carcinoma, has been dedicated to the public by the institutions that made the discovery, The Rockefeller University (“Rockefeller”) and the New York Genome Center (“NYGC”). The institutions made this unusual move in the hope of accelerating progress toward the delivery of diagnostics and therapies for the devastating disease.

The intellectual property was described in an international PCT patent application, “Fusion Proteins and Methods of Use Thereof,” [PCT/US2014/057580] and is based on research described in the journal Science in February 2014. With today’s dedication, scientists worldwide, whether working in academia or industry, are free to use the technology described in the patent application without proprietary constraints.

The research was initiated by Sanford Simon, professor and head of the Laboratory of Cellular Biophysics at Rockefeller. The researchers sequenced DNA and RNA at NYGC from tumors that had been surgically removed from 15 people with fibrolamellar. NYGC computational biologists and members of the Simon laboratory at Rockefeller discussed the possibility of using a series of computer algorithms to search for sequence differences between the tumor samples and samples of healthy liver tissue. One abnormality that was quite evident, and was present in all 15 patients was a piece of DNA that had been broken and incorrectly rejoined, creating a mutated gene that had the potential to wreak havoc in the bodies of individuals with the gene. This translocation, the abnormal protein that results from it, and any diagnostics and therapeutics derived from the information are the subject of the intellectual property being dedicated to the public today.

The work, to which researchers from Memorial Sloan Kettering Cancer Center also significantly contributed, was accomplished using tissue samples donated for research by young people who had undergone surgery for fibrolamellar hepatocellular cancer. Financial support was provided by families and friends of young people whose lives had been touched by the disease, and by generous research funding from the Fibrolamellar Cancer Foundation. Additional support was also provided by the Howard Hughes Medical Institute, the New York Genome Center, The Rockefeller University Center for Clinical and Translational Science and by a gift to The Rockefeller University by an anonymous donor.

“The finding of this previously undiscovered mutation represents the best of what can be accomplished when scientists cross institutional boundaries and join forces to generate genomic discovery,” says Russ Carson, chair of The Rockefeller University’s Board and co-chair of the New York Genome Center’s Board.

“The institutions who today donate this intellectual property to the public firmly believe that making the technology freely available is in the best interests of the patients, families, and philanthropists whose support made its discovery possible.”

Source: Rockefeller University

Featured news from related categories:

Technology Org App
Google Play icon
85,377 science & technology articles

Most Popular Articles

  1. New treatment may reverse celiac disease (October 22, 2019)
  2. "Helical Engine" Proposed by NASA Engineer could Reach 99% the Speed of Light. But could it, really? (October 17, 2019)
  3. New Class of Painkillers Offers all the Benefits of Opioids, Minus the Side Effects and Addictiveness (October 16, 2019)
  4. The World's Energy Storage Powerhouse (November 1, 2019)
  5. Plastic waste may be headed for the microwave (October 18, 2019)

Follow us

Facebook   Twitter   Pinterest   Tumblr   RSS   Newsletter via Email