The commercial release of 3D printed liver tissue was announced earlier this week. Organovo is the company behind the release. The product is intended for use for preclinical drug discovery testing to see if the drugs are toxic or not. This is intended to provide data to help predict liver tissue toxicity or ADME (absorption, distribution, metabolism and excretion) outcomes in later-stage preclinical drug discovery programs. The product is called exVive3D Human Liver Tissue. According to the company, “The durability and functionality of the 3D liver product enable the assessment of the effects of low dose or repeated dosing regimens across a spectrum of biochemical, molecular, and histologic end points.”
Cross-section of multi-cellular bioprinted human liver tissue, stained with hematoxylin & eosin (H&E).
San Diego, California-based Organovo is described as a 3D biology company focused on 3D “bioprinting” technology. As the company explains, bioprinting combines the potential of engineering and biology to create living human tissues that mimic the form and function of native tissues. Bio-ink building blocks are dispensed from a bioprinter. This is a layer-by-layer approach scaled for the target output.
Read more at: MedicalXpress