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Seeking the causes of hyperactivity

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Posted April 30, 2014
Seeking the causes of hyperactivity
Neurotransmitter receptors are withdrawn into the post-synaptic cell, where they are transported via membranous cell components called early endosomes (EEAs). This figure shows that LMTK3 is closely located with these EEAs, although the exact nature of that relationship is unknown. LMTK3 is shown in green and EEA1 is shown in red.

The 60 trillion cells that comprise our bodies communicate constantly. Information travels when chemical compounds released by some cells are received by receptors in the membrane of another cell. In a paper published in the Journal of Neuroscience, the OIST Cell Signal Unit, led by Professor Tadashi Yamamoto, reported that mice lacking an intracellular trafficking protein called LMTK3, are hyperactive. Hyperactivity is a behavioral disorder that shows symptoms including restlessness, lack of coordination, and aggressive behavior. Identifying the genetic factors that contribute to such behaviors may help to explain the pathological mechanisms underlying autism and Attention Deficit Hyperactivity Disorder, ADHD, in humans.

LMTK3 is abundant in two brain regions: the cerebral cortex, which coordinates perception, movement, and thought, and the hippocampus, which governs memory and learning. In the brain, neurons communicate via connections called synapses. To send a message, a nerve terminus in the pre-synapse releases neurotransmitters to be received by the post-synaptic receptors.

Read more at: MedicalXpress

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