One example of ancient oxygen-requiring biochemical pathway in eukaryotes is the biosynthesis of sterols, producing cholesterol in animals and ergosterol in fungi.
The mechanism regulating the sterol pathway is widely conserved between animals and fungi and centres on a protein family of transcription activators named the sterol regulatory element binding proteins (SREBPs), which form part of a sterol-sensing complex.
However, in one group of fungi; the Saccharomycotina, which includes the model yeast Saccharomyces cerevisiae and the major pathogen Candida albicans, control of the sterol pathway has been taken over by an unrelated regulatory protein, Upc2.
New research published in PLoS Genetics by UCD researchers, in collaboration with colleagues from AgroParisTech, France and the University of Kansas, USA, used comparative genomic analysis to investigate the timing of the evolutionary switch from one regulatory mechanism to another; from SREBPs to Upc2.
Read more at: Phys.org