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Discovery spotlights key role of mystery RNA modification in cells

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Posted January 7, 2014
Discovery spotlights key role of mystery RNA modification in cells
University of Chicago graduate student Xiao Wang and her colleagues based the results of their Nature paper on RNA modification on analysis of HeLa cells, a line of human cells widely used in laboratory research. Credit: Rob Kozloff/University of Chicago
Researchers had known for several decades that a certain chemical modification exists on messenger ribonucleic acid (mRNA), which is essential to the flow of genetic information. But only recently did experiments at the University of Chicago show that one major function of this modification governs the longevity and decay of RNA, a process critical to the development of healthy cells.

The chemical modification on mRNA in question is called N6-methyladenosine (m6A). A recent study by UChicago scientists reveals how the m6A modification on mRNA could affect the half life of mRNA that in turn regulates cellular protein quantities That discovery could provide fundamental insights into healthy functioning and disorders such as obesity, diabetes, and infertility.

The m6A modification “affects a huge number of messenger RNA in human cells, and yet we did not know its exact function,” said Chuan He, professor in chemistry at UChicago and a recently selected investigator of the Howard Hughes Medical Institute. He, Xiao Wang and 11 co-authors from UChicago, University of California, San Diego, and Peking University reported their findings on m6A in the Jan. 2 issue of Nature.

Read more at: Phys.org

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