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Over 40 genetic links to rheumatoid arthritis discovered

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Posted December 27, 2013
Rheumatoid arthritis research shows the potential of large-scale genetic studies for drug discovery
The results of the largest international study to date into the genetic basis of rheumatoid arthritis, published in the journal Nature, shed light on the biology of the disease and provide evidence that large-scale genetic studies can assist in the identification of new drugs for complex disorders such as rheumatoid arthritis. Credit: RIKEN
A meta-analysis identifying 42 new genetic links to rheumatoid arthritis opens the door to increasing the medical tool box for the autoimmune disorder.

The study is to be published on-line in Nature on December 25. One of Canada’s pre-eminent researchers of autoimmune disease, Dr. Kathy Siminovitch, played a leading role in the study.

Rheumatoid arthritis is a leading cause of disability world-wide, afflicting up to one in a hundred individuals, according to World Health Organization estimates. About half of adults with the autoimmune disease are unable to work full time within 10 years of diagnosis. The findings of this study by an international consortium of researchers, including Dr. Siminovitch, offer new potential targets for therapy. She is the Director of the Office of Personalized Genomics and Innovative Medicine at Mount Sinai Hospital and a Senior Investigator at the hospital’s Lunenfeld-Tanenbaum Research Institute in Toronto, Canada.

Read more at: MedicalXpress

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