The discovery, based on a comprehensive study in a mouse model of atherosclerosis, contradicts a long-held hypothesis about the role of iron in the disease and carries important implications for patients with chronic kidney disease or anemia related to inflammatory disorders, many of whom receive high-dose iron supplementation therapy. The findings currently appear online in the peer-reviewed journal Cell Reports.
“Understanding risk factors for atherosclerosis progression is important for better prevention and treatment of the disease,” said senior author Elizabeta Nemeth, a professor of medicine at the David Geffen School of Medicine at UCLA and co-director of the UCLA Center for Iron Disorders. “For many years, there has been a belief that higher iron levels might contribute to, or worsen, atherosclerosis. We found no such connection.”
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