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The team of proteins that could have implications for the fight against cancer

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Posted August 8, 2013
The mitotic spindle in a human cell: showing TACC 3 in green, clathrin in red and chromosomes in blue. Credit: Royle

The mitotic spindle in a human cell: showing TACC 3 in green, clathrin in red and chromosomes in blue. Credit: Royle

Researchers at Warwick Medical School have identified the key role played by a team of proteins in the process of mitosis. Working out how to control them may give scientists a way to destroy cancerous cells.

 

The study, published in The Journal of Cell Biology, highlights the role of a newly identified team of proteins, TACC3-ch-TOG-clathrin, in forming inter-microtubule bridges that stabilise the kinetochore fibres (K-fibres) used in mitosis.

When a cell divides, it produces a mitotic spindle which then makes sure that the chromosomes are divided equally between the two new cells. Failure to do so efficiently can lead to problems; those cells with either too few or too manychromosomes are at risk of becoming cancerous.

In order to do this the mitotic spindle uses K-fibres to allow for chromosome movement around the cell. These fibres are comprised of even smaller microtubules, bundled together via what may be termed ‘bridges’ – which is where the team of proteins comes in.

Clathrin is a protein that is involved in the process of membrane trafficking in interphase cells, but it switches role during mitosis and localises to the mitotic spindle where it works alongside TACC3 and ch-TOG to form these bridges.

When TACC3 is removed from the cell, the clathrin is no longer able to bind the microtubules. Other bridges do exist but they only represent about 40% of the total so the microtubules, and as a result the mitotic spindle, are significantly weaker.

Read more at: Phys.org

 

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