Researchers at Columbia University Medical Center, working with their collaborators at the Hospital for Special Surgery, have created a fleet of molecular “robots” that can home in on specific human cells and mark them for drug therapy or destruction.
The nanorobots—a collection of DNA molecules, some attached to antibodies —were designed to seek a specific set of human blood cells and attach a fluorescent tag to the cell surfaces. Details of the system were published July 28, 2013, in the online edition of Nature Nanotechnology.
“This opens up the possibility of using such molecules to target, treat, or kill specific cells without affecting similar healthy cells,” said the study’s senior investigator, Milan Stojanovic, PhD, associate professor of medicine and of biomedical engineering at Columbia University Medical Center. “In our experiment, we tagged the cells with a fluorescent marker; but we could replace that with a drug or with a toxin to kill the cell.”
Though other DNA nanorobots have been designed to deliver drugs to cells, the advantage of Stojanovic’s fleet is its ability to distinguish cell populations that do not share a single distinctive feature.
Cells, including cancer cells, rarely possess a single, exclusive feature that sets them apart from all other cells. This makes it difficult to design drugs without side effects. Drugs can be designed to target cancer cells with a specific receptor, but healthy cells with the same receptor will also be targeted.
Read more at: Phys.org