Google Play icon

Novel molecules to target the cytoskeleton

Share
Posted August 2, 2013
Growth of lamellar networks of actin filaments after the addition of the new compounds (compare the cell contours on the left and right). Credit: ISIS/IGBMC

Growth of lamellar networks of actin filaments after the addition of the new compounds (compare the cell contours on the left and right). Credit: ISIS/IGBMC

The dysfunction of the cytoskeleton, a constituent element of the cell, is often associated with pathologies such as the onset of metastases. For this reason, it is a target of interest in numerous therapies. Teams from CNRS, the Université de Strasbourg and Inserm, led by Daniel Riveline, Jean-Marie Lehn and Marie-France Carlier, have synthesized molecules capable of causing rapid growth of actin networks, one of the components of the cytoskeleton. This is a breakthrough because, until now, only molecules that stabilize or destroy the cytoskeleton of actin have been available. These compounds with novel properties, whose action has been elucidated both in vitro and in vivo, provide a new tool in pharmacology. This work was published in the journal Nature Communications on 29 July 2013.

The cytoskeleton is mainly composed of actin filaments and microtubules. Made of polymers in dynamic assembly and constantly constructing and deconstructing itself, it affects numerous cellular processes such as intracellular movement, division and transport. It is involved in key steps of embryogenesis and other processes essential to life. Consequently, its malfunctioning can lead to serious pathologies. For example, the onset of certain metastases is revealed by an increased activity of the cytoskeleton. Identifying new molecules that target the cytoskeleton thus represents a major challenge.

Read more at: Phys.org

Featured news from related categories:

Technology Org App
Google Play icon
86,181 science & technology articles

Most Popular Articles

  1. Scientists Reverse Dementia in Mice with Anti Inflammatory Drugs (December 5, 2019)
  2. NASA Scientists Confirm Water Vapor on Europa (November 19, 2019)
  3. How Do We Colonize Ceres? (November 21, 2019)
  4. Toyota Raize a new cool compact SUV that we will not see in this part of the world (November 24, 2019)
  5. Universe is a Sphere and Not Flat After All According to a New Research (November 7, 2019)

Follow us

Facebook   Twitter   Pinterest   Tumblr   RSS   Newsletter via Email