Google Play icon

A better route to hydrocarbazoles

Share
Posted June 26, 2013

abetterroute[1]

A new chemical process developed by researchers at Kanazawa University provides an efficient way of synthesizing diverse organic compounds. This research is also described in the inaugural June 2013 issue of the Kanazawa University Research Bulletin: https://www.kanazawa-u.ac.jp/research_bulletin/index.html

Jun-ichi Matsuo and co-workers in the School of Pharmaceutical Sciences aimed to produce a wide variety of aromatic compounds called hydrocarbazoles, which are found in many natural substances such as strychnine. Hydrocarbazoles contain a benzene ring linked by a six-membered carbon ring and a five-membered carbon ring containing nitrogen.

Various methods exist for synthesizing hydrocarbazoles by reacting electron-accepting compounds, called enophiles, with indoles – common aromatic structures that are found in flower scents. Because this reaction involves the addition of a cyclic carbon ring, it is called cycloaddition.

Previous cycloaddition methods have been restricted to certain combinations of indoles and enophiles. Moreover, it has been difficult to control exactly where on the molecules the bonds will be formed, and thus what exact chemical structure will come out.

The new process developed by Matsuo and co-workers involves a reaction of cyclobutanones with so-called Lewis acids – molecules that can accept two electrons – to produce an intermediary molecule that has positively- and negatively-charged parts, but zero charge overall. This intermediary can react with many different indoles to produce hydrocarbazoles.

Read more at: Phys.org

Featured news from related categories:

Technology Org App
Google Play icon
85,377 science & technology articles

Most Popular Articles

  1. New treatment may reverse celiac disease (October 22, 2019)
  2. "Helical Engine" Proposed by NASA Engineer could Reach 99% the Speed of Light. But could it, really? (October 17, 2019)
  3. New Class of Painkillers Offers all the Benefits of Opioids, Minus the Side Effects and Addictiveness (October 16, 2019)
  4. The World's Energy Storage Powerhouse (November 1, 2019)
  5. Plastic waste may be headed for the microwave (October 18, 2019)

Follow us

Facebook   Twitter   Pinterest   Tumblr   RSS   Newsletter via Email