Google Play icon

Deciphering the information processing of synapses and neurons

Share
Posted June 10, 2013
This news or article is intended for readers with certain scientific or professional knowledge in the field.

A research group led by Hajime Fujii and Haruhiko Bito at the Department of Neurochemistry, Graduate School of Medicine, the University of Tokyo, has developed a novel imaging platform, dFOMA or dual FRET with Optical MAnipulation, and examined how the information contained in the frequency and number of neurotransmitter releases is transformed into postsynaptic Ca2+ signaling.

dFOMA imaging reveals unsuspected non-linearity in information processing governed by synaptic Ca2+-dependent enzymes, CaMKIIalpha and calcineurin, which are activated during synaptic plasticity and learning & memory

dFOMA imaging reveals unsuspected non-linearity in information processing governed by synaptic Ca2+-dependent enzymes, CaMKIIalpha and calcineurin, which are activated during synaptic plasticity and learning & memory

Their results uncover striking rules performed by femto-nanoliter spaces near and at the synapse of neurons. Thus, Ca2+/CaM-dependent synaptic enzymes, such as CaMKII and calcineurin, are activated through non-linear decoding mechanisms.

CaMKIIα activity sums supralinearly and senses both higher frequency and input number, acting as an input frequency/number decoder. In contrast, calcineurin activity summates sublinearly with increasing input number and shows little frequency-dependence, thus functioning as an input number counter.

These results provide evidence that CaMKIIα and calcineurin are fine-tuned to unique bandwidths and compute input variables in an asymmetric manner. Deciphering the enzymatic information processing at synapses provides a better understanding of the signaling machineries underlying synaptic plasticity and learning and memory.

Source: University of Tokyo

Featured news from related categories:

Technology Org App
Google Play icon
85,339 science & technology articles

Most Popular Articles

  1. New treatment may reverse celiac disease (October 22, 2019)
  2. "Helical Engine" Proposed by NASA Engineer could Reach 99% the Speed of Light. But could it, really? (October 17, 2019)
  3. New Class of Painkillers Offers all the Benefits of Opioids, Minus the Side Effects and Addictiveness (October 16, 2019)
  4. The World's Energy Storage Powerhouse (November 1, 2019)
  5. Plastic waste may be headed for the microwave (October 18, 2019)

Follow us

Facebook   Twitter   Pinterest   Tumblr   RSS   Newsletter via Email