Google Play icon

Dual-action enzyme protects esophagus

Posted May 10, 2013

The antioxidant enzyme glutathione peroxidase 7 (GPX7) is often “turned off” in esophageal adenocarcinoma and its precancerous condition known as Barrett’s esophagus.

Wael El-Rifai, M.D., Ph.D., DunFa Peng, Ph.D., and colleagues previously showed that GPX7’s antioxidant properties protect esophageal cells against oxidative damage. Now, in the journal Gut, they report that the enzyme also has tumor suppressor functions.

Restoring GPX7 in esophageal cancer cell lines suppressed cell growth by turning on cell cycle regulators, and cells with restored GPX7 had reduced tumor growth in an animal model. The researchers demonstrated that epigenetic hypermethylation (a chemical modification) of a specific promoter region – but not genetic mutations or gene loss – was associated with silencing of GPX7 in esophageal cancer cells.

Combined with previous results, the study shows that GPX7 functions both as an antioxidant and as a tumor suppressor and suggests that patients diagnosed with Barrett’s esophagus with loss of GPX7 may be at higher risk of progression to esophageal cancer.

Source: Vanderbilt University

Featured news from related categories:

Technology Org App
Google Play icon
85,440 science & technology articles

Most Popular Articles

  1. New treatment may reverse celiac disease (October 22, 2019)
  2. "Helical Engine" Proposed by NASA Engineer could Reach 99% the Speed of Light. But could it, really? (October 17, 2019)
  3. New Class of Painkillers Offers all the Benefits of Opioids, Minus the Side Effects and Addictiveness (October 16, 2019)
  4. The World's Energy Storage Powerhouse (November 1, 2019)
  5. Plastic waste may be headed for the microwave (October 18, 2019)

Follow us

Facebook   Twitter   Pinterest   Tumblr   RSS   Newsletter via Email