Variations in non-coding sections of the genome might be important contributors to type 2 diabetes risk, according to a new study.
DNA sequences that don’t encode proteins were once dismissed as “junk DNA”, but scientists are increasingly discovering that some regions are important for controlling which genes are switched on.
The new study, published in Nature Genetics, is one of the first to show how such regions, called regulatory elements, can influence people’s risk of disease.
Type 2 diabetes affects over 300 million people worldwide. Genetic factors have long been known to have an important role in determining a person’s risk of type 2 diabetes, alongside other factors such as body weight, diet and age.
Many studies have identified regions of the genome where variations are linked to diabetes risk, but the function of many of these regions is unknown, making it difficult for scientists to glean insights into how and why the disease develops. Only around two per cent of the genome is made up of genes: the sequences that contain code for making proteins. Most of the remainder is shrouded in mystery.
Read more at: MedicalXpress