Study demonstrates ‘guided missile’ strategy to kill hidden HIV

Share via AddThis
Posted on January 10, 2014
UNC research demonstrates 'guided missile' strategy to kill hidden HIV
This is a scanning electron micrograph of HIV-1 virions budding from a cultured lymphocyte. Credit: CDC Public Image Library
Researchers at the UNC School of Medicine have deployed a potential new weapon against HIV – a combination therapy that targets HIV-infected cells that standard therapies cannot kill.

Using mouse models that have immune systems composed of human cells, researchers led by J. Victor Garcia, PhD, found that an antibody combined with a bacterial toxin can penetrate HIV-infected cells and kill them even though standard antiretroviral therapy, also known as ART, had no effect. Killing these persistent, HIV-infected cells is a major impediment to curing patients of HIV.

“Our work provides evidence that HIV-infected cells can be tracked down and destroyed throughout the body,” said Garcia, professor of medicine and senior author of the study published January 9 in the journal PloS Pathogens.

For people with HIV, ART is life-saving treatment that can reduce the amount of virus in the body to undetectable levels. But as soon as treatment is stopped, the virus begins to replicate again. This means that people with HIV must be on medications for life. For some people, therapies are not without serious side effects.

In patients on ART, the virus either remains dormant or it multiplies very slowly – it persists, hidden, even though a cocktail of drugs is aligned against it.

Read more at: MedicalXpress



44,383 science & technology articles

Categories

Our Articles (see all)

General News

Follow us

Facebook   Twitter   Pinterest   StumbleUpon   Plurk
Google+   Tumblr   Delicious   RSS   Newsletter via Email

Featured Video (see all)

3dtau
Glasses-free 3D screen technology
Stereo-Step-Eclipse technology provides the ability to display video in stereoscopic 3D on a screen.The patent-pending technology is created…

Featured Image (see all)


Space Image: Pluto’s moon Charon
Icy world Charon is 1,200 kilometers across. That makes Pluto’s largest moon only about 1/10th the size of…