Gene therapy for human skin disease produces long-term benefits

Share via AddThis
Posted on December 27, 2013

Stem cell-based gene therapy holds promise for the treatment of devastating genetic skin diseases, but the long-term clinical outcomes of this approach have been unclear. In a study online December 26th in the ISSCR’s journal Stem Cell Reports, published by Cell Press, researchers evaluated a patient with a genetic skin disorder known as epidermolysis bullosa (EB) nearly seven years after he had undergone a gene therapy procedure as part of a clinical trial. The study revealed that a small number of skin stem cells transplanted into the patient’s legs were sufficient to restore normal skin function, without causing any adverse side effects.

 

“These findings pave the way for the future safe use of epidermal stem cells for combined cell and gene therapy of epidermolysis bullosa and other genetic skin diseases,” says senior study author Michele De Luca of the University of Modena and Reggio Emilia.

EB is a painful condition that causes the skin to be very fragile and to blister easily, and it can also cause life-threatening infections. Because there is no cure for the disease, current treatment strategies focus on relieving symptoms. To evaluate stem cell-based gene therapy as a potential treatment, De Luca and his colleagues previously launched a phase I/II clinical trial at the University of Modena and recruited an EB patient named Claudio. The researchers took  from Claudio’s palm, corrected the genetic defect in these cells, and then transplanted them into Claudio’s upper legs.

Read more at: MedicalXpress



39,865 science & technology articles

Categories

Our Articles (see all)

General News

Follow us

Facebook   Twitter   Pinterest   StumbleUpon   Plurk
Google+   Tumblr   Delicious   RSS   Newsletter via Email

Featured Video (see all)


Clean up your life with chemistry life hacks
Ever run out of your go-to cleaning product, and you’ve got a mess that you just can’t leave…

Featured Image (see all)


Multi-Utility Technology Testbed Aircraft On the Runway
The X-56A Multi-Utility Technology Testbed (MUTT) is greeted on an Edwards Air Force Base runway by a U.S.…