The preferred medical term for act of snorting is insufflation. While insufflation is an obvious choice to deliver drugs to the sinuses or lungs, it is now appreciated that many bioactive agents can get much further than that. One major advantage of this method is the low barrier of entry through the mucous membranes into the bloodstream. Although some pro-drugs, like codeine, require absorption through the gut to pass to the liver where they can be metabolized into an active form, many other drugs are compromised by a digestive passage. What’s more important though here for the brain, is that the normally-intact blood brain barrier can by bypassed either by slipping around the perineural sheath cells, or getting endocytosed and retrogradely transported along either the olfactory nerves, or the trigeminal nerves.
Read more at: MedicalXpress