Bioengineers find method to strongly adhere hydrogels to hydrophobic silicone substrates

Share via AddThis
Posted July 10, 2013
Fibroblasts cultured on RGD-alginate hydrogel became aligned perpendicular to the direction of cyclic stretching (arrow). University of Illinois bioengineers have found a way to strongly adhere hydrogels to hydrophobic silicone substrates, an innovation that provides a valuable new tool for microscale biotechnology. Credit: Cha, C., Antoniadou, E., Lee, M., Jeong, J. H., Ahmed, W. W., Saif, T. A., Boppart, S. A. and Kong, H. (2013), Tailoring Hydrogel Adhesion to Polydimethylsiloxane Substrates Using Polysaccharide Glue . Angew. Chem. Int. Ed.,doi: 10.1002/anie.201302925

Fibroblasts cultured on RGD-alginate hydrogel became aligned perpendicular to the direction of cyclic stretching (arrow). University of Illinois bioengineers have found a way to strongly adhere hydrogels to hydrophobic silicone substrates, an innovation that provides a valuable new tool for microscale biotechnology. Credit: Cha, C., Antoniadou, E., Lee, M., Jeong, J. H., Ahmed, W. W., Saif, T. A., Boppart, S. A. and Kong, H. (2013), Tailoring Hydrogel Adhesion to Polydimethylsiloxane Substrates Using Polysaccharide Glue . Angew. Chem. Int. Ed.,doi: 10.1002/anie.201302925

Introductory chemistry students learn that oil and water repel each other. So do other hydrophobic substances, which carry no electric charge, and hydrophilic substances, which carry an electric charge that allows them to mix with water.

 

In a study reported in the July 1, 2013 Angewandte Chemie, a group of University of Illinois bioengineers have found a way to strongly adhere hydrogels to hydrophobic silicone substrates, an innovation that provides a valuable new tool for microscale biotechnology. The article reporting the work was highlighted by the editors as a “Hot Paper” in Soft Material Chemistry.

Microscale biotechnologies, including cell culture platforms and biochips, have important applications in genomics, tissue engineering, and many other areas of biology. Silicone polymers are often used as a component material in these technologies because of their advantageous properties: silicones are inert, elastic, biocompatible, and easy to work with.

One major drawback of this type of material in biological applications is that surfaces formed by silicones are extremely hydrophobic. These surfaces therefore prohibit easy flow of aqueous solutions and prevent the binding of some biomolecules, while promoting undesired binding of others. Chemical modifications or coatings can be used to make the surfaces hydrophilic, but the results produced by these treatments are temporary.

Read more at: Phys.org



54,110 science & technology articles

Categories

Our Articles (see all)

General News

Follow us

Facebook   Twitter   Pinterest   StumbleUpon   Plurk
Google+   Tumblr   Delicious   RSS   Newsletter via Email

Featured Video (see all)


Using static electricity, insect-sized flying robots can land and stick to surfaces
Small drones need to stay aloft do their jobs — whether that’s searching for dangerous gas leaks or…

Featured Image (see all)

NASA’s rodent habitat, developed at Ames Research Center in Moffett Field, California, serves as a home away from home for mice on the International Space Station. Previous rodent experiments aboard space shuttles contributed to the development of new drugs now fighting osteoporosis on Earth.

Credits: NASA
Mice Studies in Space Offer Clues on Bone Loss
Astronauts know their bodies will be tested during time spent on the International Space Station, from the 15…