Brain regions active in anxiety and performance determined

Share via AddThis
Posted June 11, 2013
This news or article is intended for readers with certain scientific knowledge in the field.

Despite increasing interest in anxiety and psychological stress in daily life, little is known about neural correlates that underlie maintained psychological stress and their relationship with anxiety. In particular, the activation characteristics of lateral prefrontal subregions and their relationship with anxiety and cognitive performance under maintained psychological stress remain unknown.

Prefrontal subregions play distinct roles in mediating anxiety and performance under maintained psychological stress. © Ryu Takizawa.

Prefrontal subregions play distinct roles in mediating anxiety and performance under maintained psychological stress. © Ryu Takizawa.

Dr Ryu Takizawa and Professor Kiyoto Kasai in Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo used near-infrared spectroscopy (NIRS), a noninvasive and “real-world” functional neuroimaging method, to investigate hemodynamic responses in wide areas of the prefrontal cortex (PFC) and the influence of anxiety under conditions of maintained stress induced by a continuous arithmetic task (2 sets, 15 min each) performed in a natural sitting posture.

Although anxiety and performance are not directly correlated, the hemodynamic response in the medial portion of the lateral PFC (dorsolateral and frontopolar PFC) was significantly associated with anxiety, while hemodynamic responses in the ventrolateral PFC were associated with performance. This is the first study to suggest that PFC sub-regions play distinct roles in mediating anxiety and performance under maintained psychological stress and may lead to a better understanding of neural correlates for anxiety in everyday life.

This study was supported by grants from the Ministry of Health, Labour, and Welfare, and the “Development of biomarker candidates for social behavior” project of the Strategic Research Program for Brain Sciences sponsored by MEXT.

Source: University of Tokyo



54,172 science & technology articles

Categories

Our Articles (see all)

General News

Follow us

Facebook   Twitter   Pinterest   StumbleUpon   Plurk
Google+   Tumblr   Delicious   RSS   Newsletter via Email

Featured Video (see all)


Force-feeling phone: Software lets mobile devices sense pressure
What if you could dial 911 by squeezing your smartphone in a certain pattern in your palm? A…

Featured Image (see all)

NASA’s rodent habitat, developed at Ames Research Center in Moffett Field, California, serves as a home away from home for mice on the International Space Station. Previous rodent experiments aboard space shuttles contributed to the development of new drugs now fighting osteoporosis on Earth.

Credits: NASA
Mice Studies in Space Offer Clues on Bone Loss
Astronauts know their bodies will be tested during time spent on the International Space Station, from the 15…